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Oddsmakers project the Royals as a close favorite (-112 moneyline odds) against the Padres (-107). The Kansas City Royals will hand the ball to Seth Lugo (4-5, 3.05 ERA), who is looking for win No. 5 on the season, and the Padres will counter with Randy Vasquez (3-4, 3.70 ERA).

Padres right fielder Fernando Tatis Jr. belts a three-run home run during the seventh inning against the Kansas City Royals, turning a 2-1 game into a 5-1 game on Saturday, June 21, 2025 at Petco Park in San Diego. Denis Poroy Imagn Images