Heterogeneous Hippo pathway (YAP/TAZ) activation in lung adenocarcinoma drives tumor progression by enabling ferroptosis ...

Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

Single cells are typically typed by clustering into discrete locations in reduced dimensional transcriptome space. Here we introduce Stator, a data-driven method that identifies cell (sub)types and ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

The dissemination of transferable plasmids, a major type of mobile genetic elements (MGEs), is one main driver of antibiotic resistance outbreaks. While the plasmid persistence condition in well-mixed ...

Spatial proteomics (SP) encompasses a diverse array of technologies that vary in scale, resolution, and sensitivity, offering researchers and clinicians a broad range of tools to investigate the ...

Signaling pathways play a major role in P-body dynamics and different protein kinases have been functionally associated with the regulation of P-body assembly/disassembly (Rzeczkowski et al, 2011; ...

Corneal diseases can cause severe visual impairment and even blindness, which have been linked to the interruption of corneal epithelial homeostasis. However, the underlying molecular mechanisms are ...

Metastatic progression can be associated with the acquisition of genetic, epigenomic, and metabolic characteristics that foster a tumor cell’s ability to break out of the primary site. One of the key ...

Plant arbovirus infection is regulated by a delicate interplay between virus, vector, and host. While microRNAs are known to be transmitted across species, their role as cross-kingdom effectors in ...

After the Covid-19 pandemic, pertussis has made a spectacular comeback in Europe and many other parts of the world, while during the pandemic it had essentially disappeared because of the social ...