As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

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Sensory Stimulation Systems, and GENUS, refer to a noninvasive procedure, i.e., a "digital therapeutic," being developed by Cognito Therapeutics. The company developed a wearable GammaSense ...

In a June 12 conference at UW-Madison, researchers gathered from across the U.S. and abroad to discuss the latest progress on TDP-43 biomarkers. In all, 74 people attended in person, and 727 virtually ...

Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

Single Source: National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) (U24 Clinical Trial Not Allowed) (RFA-AG-26-002) ...

NULISA assays measure AD biomarkers in blood as accurately as do gold-standard assays. A panel of 123 CNS proteins could aid differential diagnosis. It may also sharpen prognosis and profile a ...

GNPC has assembled proteomic data on 40,000 blood and CSF samples from cohorts of neurodegenerative disease. The dataset will be released for public use July 15. GNPC scientists are adding more ...

CagA disrupts bacterial biofilms. It also prevents Aβ and α-synuclein from forming fibrils. Scientists will test CagA in AD and PD mouse models to assess its therapeutic potential. Scientists estimate ...

Up-and-coming Alzheimer’s blood tests may soon be used for people with Down’s syndrome. In a longitudinal biomarker study of adults with three copies of ...

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.

In mice, exercise spurred neurogenesis in wild-type and APP/PS1 mice. The workouts induced protective gene-expression signatures across cell types in the dentate gyrus. Exercise reversed some of the ...