The San Francisco 49ers picked up their first loss of the season, falling 23-17 to the Minnesota Vikings in Week 2. A special teams error, two turnovers (interception and fumble) and two turnovers ...

The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

The San Francisco 49ers take their 1-0 record to the road against the Minnesota Vikings on Sunday. San Francisco easily took care of the Aaron Rodgers and the New York Jets at home in the season ...

Another star player on the 49ers has suffered a calf strain that will hold him out for a "couple weeks" per head coach Kyle Shanahan. The loss to the Minnesota Vikings is getting worse for the San ...

The San Francisco 49ers recently navigated a tumultuous period involving wide receiver Brandon Aiyuk, who initially sought a trade but ultimately secured a new contract with the team. The ...

A pressure-packed season for the San Francisco 49ers is already ratcheting up severely. The 49ers dropped a game to the upstart Minnesota Vikings for the second straight year on Sunday ...

LATEST Sept. 14, 10:30 a.m. The San Francisco 49ers are placing Christian McCaffrey on injured reserve on Saturday, according to multiple reports. ESPN’s Adam Schefter and NFL Network’s Ian ...

The 49ers reportedly checked in on multiple potential replacements for Brandon Aiyuk in the wake of the uncertainty surrounding the wide receiver this offseason. Before San Francisco ended their ...

The San Francisco 49ers didn't violate the NFL's rules regarding the injury status of star running back Christian McCaffrey in Week 1, the league announced on Friday. "We have looked into the ...