The Cardinals open on the road and end the season with two consecutive road games. They have two prime-time games scheduled. They have their bye week in Week 8. In 2025, as an odd year, the entire NFC will have eight home games and nine road games. The AFC will have nine home games and eight road games.

Huge home games at State Farm Stadium to keep an eye out for include contests against divisional rivals Seattle Seahawks (Sept. 25), San Francisco 49ers (Nov. 16) and Los Angeles Rams (Dec. 7) as well as a matchup with the Green Bay Packers (Oct. 19).