MyoD is a 3D genome structure organizer for muscle cell identity
WEBJan 11, 2022 · Here, we analyzed 3D genome structures in muscle cells from mice lacking the muscle lineage transcription factor (TF), MyoD, versus wild-type mice. We show that MyoD functions as a “genome ...
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
WEBSep 23, 2004 · Here we show, using an allelic series of three Myf5 mutants that differentially affect the expression of the genetically linked Mrf4 gene, that skeletal muscle is present in the new Myf5:Myod double-null mice only when Mrf4 expression is not compromised.
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
WEBSep 23, 2004 · Here we show, using an allelic series of three Myf5 mutants that differentially affect the expression of the genetically linked Mrf4 gene, that skeletal muscle is present in the new Myf5:Myod...
MyoD is a 3D genome structure organizer for muscle cell identity
WEBJan 11, 2022 · An unresolved question is how cell type-specific 3D genome structures are established during development. Here, we analyzed 3D genome structures in muscle cells from mice lacking the muscle lineage transcription factor …
The Myogenic Regulatory Factors, Determinants of Muscle …
WEBJan 1, 2020 · Remarkably in Myf5 mutant mice, the onset of MyoD expression occurs normally, which is followed by the expression of Myogenin. These results suggested that the activation of MyoD occurs independently of Myf5 and that MyoD can substitute for the absence of Myf5 in the development of skeletal muscle .
Master control: transcriptional regulation of mammalian Myod
WEBJul 12, 2019 · In adult skeletal muscle, Myod mRNA exhibits circadian rhythm which is abolished in mice mutant for Clock or Bmal1, two bHLH-PAS domain transcription factors that heterodimerize to positively regulate the circadian clock through binding E-boxes in target gene loci.
WEBmuscle lineage transcription factor (TF), MyoD, versus wild-type mice. We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle
MyoD is required for myogenic stem cell function in adult ... - PubMed
WEBMay 15, 1996 · To investigate the function of MyoD in adult skeletal muscle, we interbred MyoD mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mice lacking both MyoD and dystrophin displayed a marked increase in severity of myopathy leading to premature death, suggesting a role for M ….
MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice
WEBNov 1, 1994 · The expression pattern of myogenic regulatory factors and myotome-specific contractile proteins was studied during embryonic development of Myf-5 mutant mice by in situ hybridization and immunohistochemistry.
Overlapping functions of the myogenic bHLH genes MRF4 and MyoD …
WEBJul 1, 1998 · In mice lacking myogenin, there is a severe deficiency of skeletal muscle, but some residual muscle fibers are present in mutant mice at birth. Mice lacking MRF4 are viable and have skeletal muscle, but they upregulate myogenin expression, which could potentially compensate for the absence of MRF4.